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" Oh well, I try so hard to be his friend - and maybe someday that will happen! Trump (@real Donald Trump) November 12, 2017Does the Fake News Media remember when Crooked Hillary Clinton, as Secretary of State, was begging Russia to be our friend with the misspelled reset button? More »

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This mechanism was first described for the picornavirus family, where it allows continued synthesis of viral proteins when cap-dependent scanning is reduced by viral modification of e IFs (Belsham and Jackson 2000). This implies that internal initiation is an important cellular mechanism for regulating translation and not just a specialized viral strategy. There are four human variants of PTB: PTB-1, PTB-2, PTB-4 (Wagner and Garcia-Blanco 2001), and n PTB, an isoform that shows increased expression in neuronal tissues (Markovtsov et al. 2000), and it was suggested that RRM2 is required for PTB oligomerization (Perez et al. However, recent data have shown that all four RRMs interact with the RNA, and that PTB exists as a monomer in solution with an elongated structure consistent with a linear arrangement of the RRMs (Simpson et al. Using SELEX, the optimal binding site for PTB-1 has been defined as 5′-CAGCCUGGUGCCUCU CUUUCGG-3′ (Singh et al. More »